749 research outputs found
Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent
A hallmark of electrophysiological brain activity is its 1/f-like spectrum â power decreases with increasing frequency. The steepness of this âroll-offâ is approximated by the spectral exponent, which in invasively recorded neural populations reflects the balance of excitatory to inhibitory neural activity (E:I balance). Here, we first establish that the spectral exponent of non-invasive electroencephalography (EEG) recordings is highly sensitive to general (i.e., anaesthesia-driven) changes in E:I balance. Building on the EEG spectral exponent as a viable marker of E:I, we then demonstrate its sensitivity to the focus of selective attention in an EEG experiment during which participants detected targets in simultaneous audio-visual noise. In addition to these endogenous changes in E:I balance, EEG spectral exponents over auditory and visual sensory cortices also tracked auditory and visual stimulus spectral exponents, respectively. Individualsâ degree of this selective stimulusâbrain coupling in spectral exponents predicted behavioural performance. Our results highlight the rich information contained in 1/f-like neural activity, providing a window into diverse neural processes previously thought to be inaccessible in non-invasive human recordings
Massive Upper Gastrointestinal Bleeding Secondary to Duodenal Metastasis of Transitional Cell Carcinoma of the Urinary Bladder
Acute upper gastrointestinal (UGI) bleeding is a common problem in our clinical practice and is often due to peptic ulcer diseases. Occasionally, malignancy may be implicated in these situations. Here we report a rare case of UGI bleeding secondary to metastatic transitional cell carcinoma (TCC) of the urinary bladder. A 62-year-old man with a history of stage IIIb TCC of the urinary bladder presented with hematemesis. Endoscopy showed a large tumor in the second stage of the duodenum that occupied 40% of the duodenal circumference, over 7 cm in length. Biopsies revealed a poorly differentiated malignant neoplasm consistent with metastasis from urothelial carcinoma that was identical to the previous surgical specimen of the urinary bladder. He was treated with supportive therapy and intravenous proton pump inhibitor and was discharged home 2 weeks later. Two weeks after discharge, the patient returned to the hospital with a painful swelling of the floor of his mouth. Biopsy again showed the same cancer type. He had unremitting bleeding from his mouth requiring multiple transfusions and a course of palliative radiation therapy. He progressively deteriorated in his cardiopulmonary and neurological functions and expired with cardiopulmonary arrest one month later
Dsg2 Upregulation as a Rescue Mechanism in Pemphigus
In pemphigus vulgaris (PV), autoantibodies directed against the desmosomal cadherin desmoglein (Dsg) 3 cause loss of intercellular adhesion. It is known that Dsg3 interactions are directly inhibited by autoantibody binding and that Dsg2 is upregulated in epidermis of PV patients. Here, we investigated whether heterophilic Dsg2-Dsg3 interactions occur and would modulate PV pathogenesis. Dsg2 was upregulated in PV patientsâ biopsies and in a human ex vivo pemphigus skin model. Immunoprecipitation and cell-free atomic force microscopy (AFM) experiments demonstrated heterophilic Dsg2-Dsg3 interactions. Similarly, in Dsg3-deficient keratinocytes with severely disturbed intercellular adhesion Dsg2 was upregulated in the desmosome containing fraction. AFM revealed that Dsg2-Dsg3 heterophilic interactions showed binding frequency, strength, Ca2+-dependency and catch-bond behavior comparable to homophilic Dsg3-Dsg3 or homophilic Dsg2-Dsg2 interactions. However, heterophilic Dsg2-Dsg3 interactions had a longer lifetime compared to homophilic Dsg2-Dsg2 interactions and PV autoantibody-induced direct inhibition was significantly less pronounced for heterophilic Dsg2-Dsg3 interactions compared to homophilic Dsg3 interactions. In contrast, a monoclonal anti-Dsg2 inhibitory antibody reduced heterophilic Dsg2-Dsg3 and homophilic Dsg2-Dsg2 binding to the same degree and further impaired intercellular adhesion in Dsg3-deficient keratinocytes. Taken together, the data demonstrate that Dsg2 undergoes heterophilic interactions with Dsg3, which may attenuate autoantibody-induced loss of keratinocyte adhesion in pemphigus
Bloch oscillations, Zener tunneling and Wannier-Stark ladders in the time-domain
We present a time-domain analysis of carrier dynamics in a semiconductor
superlattice with two minibands. Integration of the density-matrix equations of
motion reveals a number of new features: (i) for certain values of the applied
static electric field strong interband transitions occur; (ii) in static fields
the complex time-dependence of the density-matrix displays a sequence of stable
plateaus in the low field regime, and (iii) for applied fields with a periodic
time-dependence the dynamic response can be understood in terms of the
quasienergy spectra.Comment: 4 pages, 6 PostScript figures available from [email protected], REVTEX
3.
Effects of impurity scattering on electron-phonon resonances in semiconductor superlattice high-field transport
A non-equilibrium Green's function method is applied to model high-field
quantum transport and electron-phonon resonances in semiconductor
superlattices. The field-dependent density of states for elastic (impurity)
scattering is found non-perturbatively in an approach which can be applied to
both high and low electric fields. I-V curves, and specifically electron-phonon
resonances, are calculated by treating the inelastic (LO phonon) scattering
perturbatively. Calculations show how strong impurity scattering suppresses the
electron-phonon resonance peaks in I-V curves, and their detailed sensitivity
to the size, strength and concentration of impurities.Comment: 7 figures, 1 tabl
Protective Endogenous Cyclic Adenosine 5'-Monophosphate Signaling Triggered by Pemphigus Autoantibodies
Pemphigus vulgaris (PV) is an autoimmune skin disease mediated by autoantibodies directed against the cadherin-type cell adhesion molecules desmoglein (Dsg) 3 and Dsg1 and is characterized by loss of keratinocyte cohesion and epidermal blistering. Several intracellular signaling pathways, such as p38MAPK activation and RhoA inhibition, have been demonstrated to be altered following autoantibody binding and to be causally involved in loss of keratinocyte cohesion. In this paper, we demonstrate that cAMP-mediated signaling completely prevented blister formation in a neonatal pemphigus mouse model. Furthermore, elevation of cellular cAMP levels by forskolin/rolipram or ÎČ receptor agonist isoproterenol blocked loss of intercellular adhesion, depletion of cellular Dsg3, and morphologic changes induced by Ab fractions of PV patients (PV-IgG) in cultured keratinocytes. Incubation with PV-IgG alone increased cAMP levels, indicating that cAMP elevation may be a cellular response pathway to strengthen intercellular adhesion. Our data furthermore demonstrate that this protective pathway may involve protein kinase A signaling because protein kinase A inhibition attenuated recovery from PV-IgGâinduced cell dissociation. Finally, cAMP increase interfered with PV-IgGâinduced signaling by preventing p38MAPK activation both in vitro and in vivo. Taken together, our data provide insights into the cellular response mechanisms following pemphigus autoantibody binding and point to a possible novel and more specific therapeutic approach in pemphigus
Zener transitions between dissipative Bloch bands. II: Current Response at Finite Temperature
We extend, to include the effects of finite temperature, our earlier study of
the interband dynamics of electrons with Markoffian dephasing under the
influence of uniform static electric fields. We use a simple two-band
tight-binding model and study the electric current response as a function of
field strength and the model parameters. In addition to the Esaki-Tsu peak,
near where the Bloch frequency equals the damping rate, we find current peaks
near the Zener resonances, at equally spaced values of the inverse electric
field. These become more prominenent and numerous with increasing bandwidth (in
units of the temperature, with other parameters fixed). As expected, they
broaden with increasing damping (dephasing).Comment: 5 pages, LateX, plus 5 postscript figure
Superfluid Dynamics of a Bose-Einstein Condensate in a Periodic Potential
We investigate the superfluid properties of a Bose-Einstein condensate (BEC)
trapped in a one dimensional periodic potential. We study, both analytically
(in the tight binding limit) and numerically, the Bloch chemical potential, the
Bloch energy and the Bogoliubov dispersion relation, and we introduce {\it two}
different, density dependent, effective masses and group velocities. The
Bogoliubov spectrum predicts the existence of sound waves, and the arising of
energetic and dynamical instabilities at critical values of the BEC
quasi-momentum which dramatically affect its coherence properties. We
investigate the dependence of the dipole and Bloch oscillation frequencies in
terms of an effective mass averaged over the density of the condensate. We
illustrate our results with several animations obtained solving numerically the
time-dependent Gross-Pitaevskii equation.Comment: 13 pages, 7 figures, movies and published paper available at
http://www.iop.org/EJ/abstract/1367-2630/5/1/11
Linear optical absorption spectra of mesoscopic structures in intense THz fields: free particle properties
We theoretically study the effect of THz radiation on the linear optical
absorption spectra of semiconductor structures. A general theoretical
framework, based on non-equilibrium Green functions, is formulated, and applied
to the calculation of linear optical absorption spectrum for several
non-equilibrium mesoscopic structures. We show that a blue-shift occurs and
sidebands appear in bulk-like structures, i.e., the dynamical Franz-Keldysh
effect [A.-P. Jauho and K. Johnsen, Phys. Rev. Lett. 76, 4576 (1996)]. An
analytic calculation leads to the prediction that in the case of superlattices
distinct stable steps appear in the absorption spectrum when conditions for
dynamical localization are met.Comment: 13 Pages, RevTex using epsf to include 8 ps figures. Submitted to
Phys. Rev. B (3 April 97
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